Our Faculty

Nigel Yarlett

Lecturer
Distinguished Professor

Dyson College of Arts and Sciences

Chemistry and Physical Sciences - NYC

Location
  • @New York City
    41 Park Row 606
Office Hours
New York City
"In the fields of observation chance favors the prepared mind." Louis Pasteur.

Biography


Awarded a Fellow of the Royal Society of Chemistry (2012); Fellow of the Society of Fellows of Pace University (1996); Hutner Prize in Protozoology (1995); Kenan Teaching Award (2003); Lady Glanely Scholarship (1978). Over 100 publications in the area of protozoan biochemistry. Demonstrated the presence of hydrogenosomes in Rumen protozoa and Rumen fungi. The role of oxygen in the resistance of Trichomonas vaginalis to metronidazole. The unique polyamine bichemistry of Trichomonas vaginalis and Cryptosporidium parvum. The ability of oxoboroles to cure mouse model trypanosomiasis. Novel culture method for Cryptosporidium parvum. Funded by the National Institutes of Health; Drugs for Neglected Diseases initiative, and the Bill and Melinda Gates Foundation.

Education


University of Wales Fellowship , Cardiff University , Cardiff, Wales, UK , 1986
Biochemical Parsitology

Visiting Fellow , Cambridge University , United Kingdom , 1986
Anaerobic Biochemistry

Post-Doctoral , Rockefeller University , New York , 1984
Biochemical Cytology

PhD , Cardiff University/Hannah Research Institute , Cardiff, Wales/ Ayr, Scotland , 1982
Biochemistry

BS , Cardiff University , Cardiff, Wales, UK , 1979
Microbiology

Awards and Honors

  • Royal Society of Chemistry, March 01, 2012 - Fellow of the Royal Society of Chemistry
  • Pace University, May 2003 - Kenan Award for Teaching Excellence
  • Pace University, July 1996 - Fellow of the Society of Fellows of Pace University
  • International Society for Protistology, June 14, 1996 - Hutner Prize
  • University of Wales, September 14, 1978 - Lady Glanely Scholarship

LICENSURES & CERTIFICATES

  • NYSDOH, September 01 - Radiation Safety Officer
    University RSO responsible for ensuring compliance with City, State and Federal guidelines. First responder in NYC for radiation emergency.

Publications


Morada, M., Lee, S., Gunther-Cummins, L., Weiss, L., Widmer, G., Tzipori, S. & Yarlett, N. Continuous culture of Cryptosporidium parvum using hollow fiber technology. International Journal of Parasitology. Vol in press

Williams, C. F., Yarlett, N., Aon, M. A. & Lloyd, D. (2014, August 04). Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol.. Molecular and Biochemical Parasitology. Vol 196 (Issue 1) , pages 45-52.

Mittal, N., Morada, M., Tripathi, P., Gowri, V. S., Mandal, S., Quirch, A., Park, M. H., Yarlett, N. & Madhubala, R. (2014, June 02). Cryptosporidium parvum has an active hypusine biosynthesis pathway. Molecular and Biochemical Parasitology. Vol 195 (Issue 1) , pages 14-22.

Bacchi, C. J., Jacobs, R. T. & Yarlett, N. (2013). New Developments in the Treatment of Late-Stage Human African Trypanosomiasis. Timo Jager, Oliver Koch and Leopold Flohe (Eds.), Weinheim, Germany: Wiley-Blackwell. Vol 4 (Issue Trypanosomatid Disease: Molecular Routes to Drug Discovery) , pages 515-529.

Wring, S., Gaukel, E., Nare, B., Jacobs, R., Beaudet, B., Bowling, T., Mercer, L., Bacchi, C. J., Yarlett, N., Randolph, R., Parham, R., Rewerts, C., Platner, J. & Don, R. (2013, September 05). Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis.. Parasitology. Vol 141 (Issue 1) , pages 104-118.

Morada, M., Pendyala, L., Wu, G., Merali, S. & Yarlett, N. (2013, August 28). Cryptosporidium parvum induces an endoplasmic response in intestinal adenocarcinoma HCT-8 cell line.. Journal of Biological Chemistry. Vol 288 (Issue 42) , pages 30356-64.

PRESENTATIONS


Upmacis, R. K., Yarlett, N. & Jordan, K. D. (2014, May). American Society for Microbiology (ASM), 114th General Meeting. Nitric Oxide Production by Trichomonas vaginalis. American Society for Microbiology, Boston

Jordan, K. D., Yarlett, N. & Upmacis, R. K. (2014, April). Second Annual Provost's Research Day. Nitric Oxide Production by Trichomonas Vaginalis. Provost's Office, Pace University

RESEARCH INTEREST


My Research is focused on the biochemistry and molecular biology of parasitic protozoa, particularly Cryptosporidia sp., and Trypanosomes. My research has resulted in the development of a new class of compound, the oxaboroles, to treat human African trypanosomiasis (HAT) that is currently in phase II clinical trials in Africa. I am also developing a novel culture system to facilitate the screening of novel compounds for the treatment of cryptosporidosis.

Grants, Sponsored Research and Contracts

Yarlett, N. (2014, October 15). Evaluation of a Continuous Culture System for Cryptosporidium sp.
Bill and Melinda Gates Foundation , Private , $198,000.00 . Funded,

Intellectual Property


  • Patent: Treatment of diseases caused by parasitic protozoa and fungal diseases by administration of 5'-deoxy-5'-(substituted) ethylthioribose compounds [Non-Provisional]
    United States
  • Patent: Adenosine compounds for the treatment of diseases caused by parasitic protozoa [Non-Provisional]
    United States
  • Patent: 5'Deoxy-5'-(substituted) alkylthioribose compounds and their pharmaceutical compositions. [Non-Provisional]
    United States

PROFESSIONAL MEMBERSHIPS

  • Royal Society of Chemistry [Fellow] , March 01 , 2012
    Advancement of Chemistry
  • New York Academy of Science , November 01 , 2011
    Society for the advancement of science.
  • American Society for Biochemistry and Molecular Biology [Member] , June 2011
    Leading organization for Biochemistry and Molecular Biology
  • International Society for Protistologists [Member at Large, Editorial Board, Treasurer] , July 01 , 1984
    Promotes Research in Eukaryotic Microbiology
  • Society for General Microbiology [Editor] , June 01 , 1979
    Advancement of Miocrobiology

COLLEGE SERVICE

  • Dyson TAP [Committee Member]
    Desc: Review TAP files from candidates seeking tenure and/or promotion

UNIVERSITY SERVICE

  • Associate Provost for Sponsored Research Review [Committee Member]
    Desc: Provide feed back from interviews and questionnaire whether Victor Goldsmith is directing the sponsored research office to its full potential.
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