Nancy Krucher

Nancy Krucher

Professor
Dyson College of Arts and Sciences
Biology
Westchester
219
Dyson Hall

Education

MS

PhD, Clarkson University, Potsdam, 1995
Cellular Biology

BS, Syracuse University, Syracuse NY, 1988
Molecular and Cellular Biology

Research and Creative Works

Research Interest

Many proteins that control cell division are involved in cancer development. The phosphorylation state of the Retinoblastoma protein (Rb) regulates the ability of this protein to control cell proliferation.

Grants, Sponsored Research and Contracts

MRI: Acquisition of high-throughput fluorescence imaging system for undergraduate research and teaching at Pace University (2019-2023)
2019 - 2023. NSF, Federal, $374,000.00. Funded.

The Role of Rb phosphorylation in proliferation an Apoptosis in breast cancer cells grown in 3D cell culture
March 2014 - February 2017. National Cancer Institute of the NIH, Federal, $360,000.00. Funded.

Courses Taught

Past Courses

BIO 101: General Biology I
BIO 231: Genetics
BIO 292: Bio Lbrtry Rsrch Training
BIO 292: Bio Lbrtry Rsrch Trng
BIO 327: Cellular Biochemistry
BIO 335: Molecular & Cellular Biology
BIO 375: Advanced Cell Biology
BIO 395: Independent Study in Biology
BIO 396: Guided Study in Biology
BIO 480: Research in Biology
BIO 481: Research in Biology II
BIO 491: Internship in Biology
BMB 710: Research I
BMB 711: Research II
CHE 329: Adv Biochemistry Laboratory
CHE 480: Research in Chemistry
ENS 600: Grad Ens - Independent Study
ENS 690: Tpc: Molecular & Cellular Bio
ENS 699: Special Topics in Env Science

Publications and Presentations

Publications

Structure–activity relationships and transcriptomic analysis of hypoxia-inducible factor prolyl hydroxylase inhibitors
(2022). Antioxidants. Vol 11 , pages 220. https://doi.org/10.3390/antiox11020220

Genetically divergent Symbiodinium sp. display distinct molecular responses to pathogenic Vibrio and thermal stress
(2014). Diseases of Aquatic Organisms. Vol 112 , pages 149-159.

Phosphorylation of the Retinoblastoma protein on Serine 807 is required for association with Bax
(2014). Cell Cycle. Vol 13 , pages 3611-3617.
DOWNLOAD

Dephosphorylation of threonine -821 of the retinoblastoma protein is required for apoptosis induced by UV and cdk inhibition
(2012). Cell Cycle.
DOWNLOAD

PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells
(2010). International Journal of Oncology.

Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase mediated apoptosis
(2008). Cancer Biology and Therapy.

Dephosphorylation of Rb (T-821) in response to cell stress
(2006). Experimental Cell Research.

Hypoxia stimulates p16 expression and association with cdk4
(2002). Experimental Cell Research.

PNUTS (PP1 targeting subunit inhibits retinoblastoma directed PP1 activity
(2002). Biochemical and Biophysical Research Communications.

Presentations

The Mammosphere- the use of a 3D model to study breast cancer
(2015, April). American Association for Cancer Research. .

Rb Association is regulated by phosphorylation
(2014, April). American Association for Cancer Research. San Diego .

Rb dephosphorylaiton and cleavage in apoptosis
(2013, April). American Association for Cancer Research. .

A single phosphorylation site mutant of Rb blocks apoptosis caused by UV stress
(2012, August). Mechanisms and Models of Cancer. Cold Spring Harbor NY.

A single phosphorylation site mutant of Rb blocks apoptosis caused by UV stress
(2012, April). American Association for Cancer Research. .

Site Specific Dephosphorylation of Rb in Apoptosis
(2011, April). American Chemical Society 59th annual undergraduate research symposium. .

Site specific dephosphorylation of Rb in Apoptosis
(2011, February). Society of fellows meeting. Pace University

Phosphatase nuclear targeting subunit is phosphorylated by the AKT kinase
(2010, April). American Association for Cancer Research. .

Related News and Stories

Pace Magazine

Biology professor Nancy Krucher, PhD, understands the transformative power of research. She’s a pioneer in the fight against breast cancer, and she’s just received a three-year $400,241 grant from the National Cancer Institute through the National Institutes of Health to study new methods to combat cancer cell development of resistance to targeted treatments.

In the Media

Pace University Professor of Biology Nancy Krucher, PhD, has received a three-year $400,241 grant from the National Cancer Institute (NCI) through the National Institutes of Health (NIH) to study new methods to combat cancer cell development of resistance to targeted treatments.